| EC |
1.14.15.4 |
| Accepted name: |
steroid 11β-monooxygenase |
| Reaction: |
a steroid + 2 reduced adrenodoxin + O2 + 2 H+ = an 11β-hydroxysteroid + 2 oxidized adrenodoxin + H2O |
| Other name(s): |
steroid 11β-hydroxylase; steroid 11β/18-hydroxylase |
| Systematic name: |
steroid,reduced-adrenodoxin:oxygen oxidoreductase (11β-hydroxylating) |
| Comments: |
A heme-thiolate protein (P-450). Also hydroxylates steroids at the 18-position, and converts 18-hydroxycorticosterone into aldosterone. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9029-66-7 |
| References: |
| 1. |
Grant, J.K. and Brownie, A.C. The role of fumarate and TPN in steroid enzymic 11β-hydroxylation. Biochim. Biophys. Acta 18 (1955) 433–434. [PMID: 13276417] |
| 2. |
Hayano, M. and Dorfman, R.I. On the mechanism of the C-11β-hydroxylation of steroids. J. Biol. Chem. 211 (1954) 227–235. [PMID: 13211659] |
| 3. |
Tomkins, G.M., Michael, P.J. and Curran, J.F. Studies on the nature of steroid 11-β hydroxylation. Biochim. Biophys. Acta 23 (1957) 655–656. [PMID: 13426185] |
| 4. |
Yanagibashi, K., Haniu, M., Shively, J.E., Shen, W.H. and Hall, P. The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11β-, 18-hydroxylation, and aldehyde synthesis. J. Biol. Chem. 261 (1986) 3556–3562. [PMID: 3485096] |
| 5. |
Zuidweg, M.H.J. Hydroxylation of Reichstein's compound S with cell-free preparations from Curvularia lunata. Biochim. Biophys. Acta 152 (1968) 144–158. [DOI] [PMID: 4967077] |
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| [EC 1.14.15.4 created 1961 as EC 1.99.1.7, transferred 1965 to EC 1.14.1.6, transferred 1972 to EC 1.14.15.4, modified 1989, modified 2014] |
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