| EC |
1.14.15.40 |
| Accepted name: |
cyclohexane-1-carboxylate 4-trans-hydroxylase |
| Reaction: |
cyclohexane-1-carboxylate + 2 reduced ferredoxin [iron-sulfur] cluster + O2 + 2 H+ = trans-4-hydroxycyclohexane-1-carboxylate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O |
| Glossary: |
trans-4-hydroxycyclohexane-1-carboxylate = trans-4-hydroxycyclohexanecarboxylate |
| Other name(s): |
chcAa (gene name) |
| Systematic name: |
cyclohexane-1-carboxylate,ferredoxin:oxygen oxidoreductase (4-trans-hydroxylating) |
| Comments: |
The enzyme, characterized from the bacterium Corynebacterium cyclohexanicum, is a cytochrome P-450 enzyme that participates in the degradation pathway of cyclohexane-1-carboxylate. The initial source of the electrons is NADH, which transfers the electrons to a specific [2Fe-2S] ferredoxin via a dedicated EC 1.18.1.3, ferredoxin—NAD+ reductase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yamamoto, T., Hasegawa, Y., Lau, P.CK. and Iwaki, H. Identification and characterization of a chc gene cluster responsible for the aromatization pathway of cyclohexanecarboxylate degradation in Sinomonas cyclohexanicum ATCC 51369. J. Biosci. Bioeng. 132 (2021) 621–629. [DOI] [PMID: 34583900] |
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| [EC 1.14.15.40 created 2024] |
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