| EC |
1.14.15.42 |
| Accepted name: |
L-tyrosine 3-nitrase |
| Reaction: |
L-tyrosine + nitric oxide + O2 + reduced ferredoxin + H+ = 3-nitro-L-tyrosine + H2O + oxidized ferredoxin |
| Other name(s): |
rufO (gene name); 3-nitro-tyrosine synthase |
| Systematic name: |
L-tyrosine,nitric oxide, reduced ferredoxin:oxygen oxidoreductase (3-nitro-L-tyrosine-forming) |
| Comments: |
A cytochrome P-450 (heme-thiolate) enzyme characterized from the bacterium Streptomyces atratus. The enzyme participates in biosynthesis of rufomycins, circular heptapeptides with anti-mycobacterial activity. The enzyme requires ferredoxin as its electron donor and catalyses a reaction in which nitric oxide is oxidized to a nitro group and inserted into L-tyrosine at the 3 position (not necessarily in this order). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Tomita, H., Katsuyama, Y., Minami, H. and Ohnishi, Y. Identification and characterization of a bacterial cytochrome P450 monooxygenase catalyzing the 3-nitration of tyrosine in rufomycin biosynthesis. J. Biol. Chem. 292 (2017) 15859–15869. [DOI] [PMID: 28774961] |
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| [EC 1.14.15.42 created 2024] |
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