| EC |
1.14.15.44 |
| Accepted name: |
3-dehydro-2,22-dideoxyecdysone 22-hydroxylase |
| Reaction: |
3-dehydro-2,22-dideoxyecdysone + O2 + 2 reduced adrenodoxin + 2 H+ = 3-dehydro-2-deoxyecdysone + H2O + 2 oxidized adrenodoxin |
| Other name(s): |
CYP302A1; Disembodied; dib (gene name) |
| Systematic name: |
3-dehydro-2,22-dideoxyecdysone,reduced adrenodoxin:oxygen oxidoreductase (22-hydroxylating) |
| Comments: |
This cytochrome P-450 (heme-thiolate) monooxygenase catalyses the second of three sequential hydroxylation reactions that occur during the biosynthesis of 20-hydroxyecdysone, the major molting hormone of arthropods. The enzyme also acts on 3-dehydro-2,22,25-deoxyecdysone and 2,22-dideoxyecdysone. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Rewitz, K.F., Rybczynski, R., Warren, J.T. and Gilbert, L.I. Identification, characterization and developmental expression of Halloween genes encoding P450 enzymes mediating ecdysone biosynthesis in the tobacco hornworm, Manduca sexta. Insect Biochem. Mol. Biol. 36 (2006) 188–199. [DOI] [PMID: 16503480] |
| 2. |
Rewitz, K.F., O'Connor, M.B. and Gilbert, L.I. Molecular evolution of the insect Halloween family of cytochrome P450s: phylogeny, gene organization and functional conservation. Insect Biochem. Mol. Biol. 37 (2007) 741–753. [DOI] [PMID: 17628274] |
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| [EC 1.14.15.44 created 2024] |
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