ExplorEnz: EC 1.14.18.5

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1.14.18.5

Accepted name:

sphingolipid C4-monooxygenase

Reaction:

a dihydroceramide + 2 ferrocytochrome b₅ + O₂ + 2 H⁺ = a (4R)-4-hydroxysphinganine ceramide + 2 ferricytochrome b₅ + H₂O

Other name(s):

sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH₂ (gene name); DEGS2 (gene name)

Systematic name:

dihydroceramide,ferrocytochrome b₅:oxygen oxidoreductase (C4-hydroxylating)

Comments:

The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b₅-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase [4].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Haak, D., Gable, K., Beeler, T. and Dunn, T. Hydroxylation of Saccharomyces cerevisiae ceramides requires Sur2p and Scs7p. J. Biol. Chem. 272 (1997) 29704–29710. [DOI] [PMID: 9368039]
2.	Grilley, M.M., Stock, S.D., Dickson, R.C., Lester, R.L. and Takemoto, J.Y. Syringomycin action gene SYR2 is essential for sphingolipid 4-hydroxylation in Saccharomyces cerevisiae. J. Biol. Chem. 273 (1998) 11062–11068. [DOI] [PMID: 9556590]
3.	Sperling, P., Ternes, P., Moll, H., Franke, S., Zähringer, U. and Heinz, E. Functional characterization of sphingolipid C4-hydroxylase genes from Arabidopsis thaliana. FEBS Lett. 494 (2001) 90–94. [DOI] [PMID: 11297741]
4.	Ternes, P., Franke, S., Zähringer, U., Sperling, P. and Heinz, E. Identification and characterization of a sphingolipid Δ⁴-desaturase family. J. Biol. Chem. 277 (2002) 25512–25518. [DOI] [PMID: 11937514]
5.	Mizutani, Y., Kihara, A. and Igarashi, Y. Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation. FEBS Lett. 563 (2004) 93–97. [DOI] [PMID: 15063729]

[EC 1.14.18.5 created 2012 as EC 1.14.13.169, transferred 2015 to EC 1.14.18.5]