| EC |
1.14.19.13 |
| Accepted name: |
acyl-CoA 15-desaturase |
| Reaction: |
(9Z,12Z)-hexadeca-9,12-dienoyl-CoA + reduced acceptor + O2 = (9Z,12Z,15Z)-hexadeca-9,12,15-trienoyl-CoA + acceptor + 2 H2O |
| Other name(s): |
DES3 (gene name) |
| Systematic name: |
acyl-CoA,reduced acceptor:oxygen oxidoreductase (15,16 cis-dehydrogenating) |
| Comments: |
The enzyme, characterized from the the plant Sorghum bicolor, is involved in the biosynthesis of sorgoleone, an allelopathic compound produced in root hair cells. The enzyme inserts a cis double bond at carbon 15. When acting on its natural substrate, (9Z,12Z)-hexadeca-9,12-dienoyl-CoA, it produces a product with a terminal double bond. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Pan, Z., Rimando, A.M., Baerson, S.R., Fishbein, M. and Duke, S.O. Functional characterization of desaturases involved in the formation of the terminal double bond of an unusual 16:3Δ(9,12,15) fatty acid isolated from Sorghum bicolor root hairs. J. Biol. Chem. 282 (2007) 4326–4335. [DOI] [PMID: 17178719] |
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| [EC 1.14.19.13 created 2015] |
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