| EC |
1.14.19.77 |
| Accepted name: |
plasmanylethanolamine desaturase |
| Reaction: |
a plasmanylethanolamine + 2 ferrocytochrome b5 + O2 + 2 H+ = a plasmenylethanolamine + 2 ferricytochrome b5 + 2 H2O |
| Glossary: |
a plasmanylethanolamine = a 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine |
| Other name(s): |
TMEM189 (gene name); 2-acyl-1-alkyl-sn-glycero-3-phosphoethanolamine desaturase; alkylacylglycerophosphoethanolamine desaturase; alkylacylglycero-phosphorylethanolamine dehydrogenase; alkyl-acylglycerophosphorylethanolamine dehydrogenase; 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylethanolamine desaturase; 1-O-alkyl 2-acyl-sn-glycero-3-phosphorylethanolamine desaturase |
| Systematic name: |
plasmanylethanolamine,ferrocytochrome b5:oxygen oxidoreductase (plasmenylethanolamine-forming) |
| Comments: |
The enzyme catalyses the introduction of a double bond at position 1 of the alkyl group attached by an ether bond at the sn-1 position of plasmanylethanolamine, generating a vinyl ether-containing plasmenylethanolamine. The enzyme is found in animals and some bacteria, but not in plants, fungi, or most aerobic bacteria. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Stoffel, W. and LeKim, D. Studies on the biosynthesis of plasmalogens. Precursors in the biosynthesis of plasmalogens: on the stereospecificity of the biochemical dehydrogenation of the 1-O-alkyl glyceryl to the 1-O-alk-1′-enyl glyceryl ether bond. Hoppe-Seylers Z. Physiol. Chem. 352 (1971) 501–511. [PMID: 5550967] |
| 2. |
Paltauf, F. Biosynthesis of plasmalogens from alkyl- and alkyl-acyl-glycerophosphoryl ethanolamine in the rat brain. FEBS Lett. 17 (1971) 118–120. [PMID: 11946011] |
| 3. |
Paltuaf, F., Prough, R.A., Masters, B.S. and Johnston, J.M. Evidence for the participation of cytochrome b5 in plasmalogen biosynthesis. J. Biol. Chem. 249 (1974) 2661–2662. [PMID: 4150797] |
| 4. |
Wykle, R.L. and Schremmer Lockmiller, J.M. The biosynthesis of plasmalogens by rat brain: involvement of the microsomal electron transport system. Biochim. Biophys. Acta 380 (1975) 291–298. [PMID: 235322] |
| 5. |
Gallego-Garcia, A., Monera-Girona, A.J., Pajares-Martinez, E., Bastida-Martinez, E., Perez-Castano, R., Iniesta, A.A., Fontes, M., Padmanabhan, S. and Elias-Arnanz, M. A bacterial light response reveals an orphan desaturase for human plasmalogen synthesis. Science 366 (2019) 128–132. [PMID: 31604315] |
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| [EC 1.14.19.77 created 1976 as EC 1.14.99.19, transferred 2020 to EC 1.14.19.77] |
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