| EC |
1.14.99.1 |
| Accepted name: |
prostaglandin-endoperoxide synthase |
| Reaction: |
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O |
| Other name(s): |
prostaglandin synthase; prostaglandin G/H synthase; (PG)H synthase; PG synthetase; prostaglandin synthetase; fatty acid cyclooxygenase; prostaglandin endoperoxide synthetase |
| Systematic name: |
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase |
| Comments: |
This enzyme acts both as a dioxygenase and as a peroxidase. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39391-18-9 |
| References: |
| 1. |
DeWitt, D.L. and Smith, W.L. Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. Proc. Natl. Acad. Sci. USA 85 (1988) 1412–1416. [DOI] [PMID: 3125548] |
| 2. |
Ohki, S., Ogino, N., Yamamoto, S. and Hayaishi, O. Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. J. Biol. Chem. 254 (1979) 829–836. [PMID: 104998] |
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| [EC 1.14.99.1 created 1972, modified 1990] |
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