The Enzyme Database

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Accepted name: deoxyhypusine monooxygenase
Reaction: [eIF5A]-deoxyhypusine + reduced acceptor + O2 = [eIF5A]-hypusine + acceptor + H2O
For diagram of reaction, click here
Glossary: deoxyhypusine = N6-(4-aminobutyl)-L-lysine
hypusine = N6-[(R)-4-amino-2-hydroxybutyl]-L-lysine
Other name(s): deoxyhypusine hydroxylase; deoxyhypusine dioxygenase
Systematic name: deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)
Comments: The enzyme catalyses the final step in the formation of the amino acid hypusine in the eukaryotic initiation factor 5A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 101920-83-6
1.  Abbruzzese, A., Park, M.H. and Folk, J.E. Deoxyhypusine hydroxylase from rat testis. Partial purification and characterization. J. Biol. Chem. 261 (1986) 3085–3089. [PMID: 3949761]
[EC created 1989]

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