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Your query returned 1 entry. Printable version
EC | 1.14.99.46 | ||||||||||
Accepted name: | pyrimidine oxygenase | ||||||||||
Reaction: | (1) uracil + FMNH2 + O2 + NADH = (Z)-3-ureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction) (1a) FMNH2 + O2 = FMN-N5-peroxide (1b) uracil + FMN-N5-peroxide = (Z)-3-ureidoacrylate + FMN-N5-oxide (1c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous) (2) thymine + FMNH2 + O2 + NADH = (Z)-2-methylureidoacrylate + H2O + FMN + NAD+ + H+ (overall reaction) (2a) FMNH2 + O2 = FMN-N5-peroxide (2b) thymine + FMN-N5-peroxide = (Z)-2-methylureidoacrylate + FMN-N5-oxide (2c) FMN-N5-oxide + NADH = FMN + H2O + NAD+ + H+ (spontaneous) |
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Glossary: | (Z)-3-ureidoacrylate = (2Z)-3-(carbamoylamino)prop-2-enoate (Z)-2-methylureidoacrylate = (2Z)-3-(carbamoylamino)-2-methylprop-2-enoate |
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Other name(s): | rutA (gene name) | ||||||||||
Systematic name: | uracil,FMNH2:oxygen oxidoreductase (uracil hydroxylating, ring-opening) | ||||||||||
Comments: | The enzyme participates in the Rut pyrimidine catabolic pathway. The flavin-N5-oxide that is formed by the enzyme reacts spontaneously with NADH to give oxidized flavin, releasing a water molecule. | ||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB | ||||||||||
References: |
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