| EC |
1.14.99.59 |
| Accepted name: |
tryptamine 4-monooxygenase |
| Reaction: |
tryptamine + reduced acceptor + O2 = 4-hydroxytryptamine + acceptor + H2O |
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For diagram of psilocybin biosynthesis, click here |
| Glossary: |
psilocybin = 3-[2-(dimethylamino)ethyl]-1H-indol-4-yl phosphate
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| Other name(s): |
PsiH |
| Systematic name: |
tryptamine,hydrogen-donor:oxygen oxidoreductase (4-hydroxylating) |
| Comments: |
A cytochrome P-450 (heme-thiolate) protein isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Fricke, J., Blei, F. and Hoffmeister, D. Enzymatic synthesis of psilocybin. Angew. Chem. Int. Ed. Engl. 56 (2017) 12352–12355. [DOI] [PMID: 28763571] |
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| [EC 1.14.99.59 created 2017] |
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