| EC |
1.14.99.60 |
| Accepted name: |
3-demethoxyubiquinol 3-hydroxylase |
| Reaction: |
5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + a reduced acceptor + O2 = 3-demethylubiquinol + acceptor + H2O |
| Glossary: |
3-demethylubiquinol = 3-methoxy-6-methyl-5-(all trans-polyprenyl)benzene-1,2,4-triol |
| Other name(s): |
6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol 5-hydroxylase; ubiF (gene name); 6-methoxy-3-methyl-2-(all-trans-polyprenyl)-1,4-benzoquinol,acceptor:oxygen oxidoreductase (5-hydroxylating) |
| Systematic name: |
5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol,acceptor:oxygen oxidoreductase (5-hydroxylating) |
| Comments: |
This prokaryotic enzyme catalyses the last hydroxylation reaction during the biosynthesis of ubiquinone. The eukaryotic enzyme is classified under EC 1.14.13.253, 3-demethoxyubiquinone 3-hydroxylase (NADH). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Kwon, O., Kotsakis, A. and Meganathan, R. Ubiquinone (coenzyme Q) biosynthesis in Escherichia coli: identification of the ubiF gene. FEMS Microbiol. Lett. 186 (2000) 157–161. [DOI] [PMID: 10802164] |
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| [EC 1.14.99.60 created 2018, modified 2024] |
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