| EC |
1.16.1.10 |
| Accepted name: |
ferric-chelate reductase [NAD(P)H] |
| Reaction: |
2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H |
| Other name(s): |
ferric reductase (ambiguous) |
| Systematic name: |
Fe(II)-siderophore:NAD(P)+ oxidoreductase |
| Comments: |
A flavoprotein. The enzyme catalyses the reduction of bound ferric iron in a variety of iron chelators (siderophores), resulting in the release of ferrous iron. The enzyme from the hyperthermophilic archaeon Archaeoglobus fulgidus is not active with uncomplexed Fe(III). cf. EC 1.16.1.7, ferric-chelate reductase (NADH) and EC 1.16.1.9, ferric-chelate reductase (NADPH). |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Vadas, A., Monbouquette, H.G., Johnson, E. and Schroder, I. Identification and characterization of a novel ferric reductase from the hyperthermophilic Archaeon Archaeoglobus fulgidus. J. Biol. Chem. 274 (1999) 36715–36721. [DOI] [PMID: 10593977] |
| 2. |
Chiu, H.J., Johnson, E., Schroder, I. and Rees, D.C. Crystal structures of a novel ferric reductase from the hyperthermophilic archaeon Archaeoglobus fulgidus and its complex with NADP+. Structure 9 (2001) 311–319. [DOI] [PMID: 11525168] |
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| [EC 1.16.1.10 created 2014] |
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