ExplorEnz: EC 1.16.3.2

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1.16.3.2

Accepted name:

bacterial non-heme ferritin

Reaction:

4 Fe(II) + O₂ + 6 H₂O = 4 [FeO(OH)] + 8 H⁺ (overall reaction)
(1a) 2 Fe(II) + O₂ + 4 H₂O = 2 [FeO(OH)] + 4 H⁺ + H₂O₂
(1b) 2 Fe(II) + H₂O₂ + 2 H₂O = 2 [FeO(OH)] + 4 H⁺

Glossary:

[FeO(OH)] = iron(III) oxide-hydroxide

Other name(s):

FtnA; HuHF

Systematic name:

Fe(II):oxygen oxidoreductase ([FeO(OH)]core-producing)

Comments:

Ferritins are intracellular iron-storage and detoxification proteins found in all kingdoms of life. They are formed from two subunits that co-assemble in various ratios to form a spherical protein shell. Thousands of mineralized iron atoms are stored within the core of the structure. The product of dioxygen reduction by the bacterial non-heme ferritin is hydrogen peroxide, which is consumed in a subsequent reaction.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Hudson, A.J., Andrews, S.C., Hawkins, C., Williams, J.M., Izuhara, M., Meldrum, F.C., Mann, S., Harrison, P.M. and Guest, J.R. Overproduction, purification and characterization of the Escherichia coli ferritin. Eur. J. Biochem. 218 (1993) 985–995. [DOI] [PMID: 8281950]
2.	Stillman, T.J., Hempstead, P.D., Artymiuk, P.J., Andrews, S.C., Hudson, A.J., Treffry, A., Guest, J.R. and Harrison, P.M. The high-resolution X-ray crystallographic structure of the ferritin (EcFtnA) of Escherichia coli; comparison with human H ferritin (HuHF) and the structures of the Fe³⁺ and Zn²⁺ derivatives. J. Mol. Biol. 307 (2001) 587–603. [DOI] [PMID: 11254384]
3.	Bou-Abdallah, F., Yang, H., Awomolo, A., Cooper, B., Woodhall, M.R., Andrews, S.C. and Chasteen, N.D. Functionality of the three-site ferroxidase center of Escherichia coli bacterial ferritin (EcFtnA). Biochemistry 53 (2014) 483–495. [DOI] [PMID: 24380371]

[EC 1.16.3.2 created 2014]