The Enzyme Database

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Accepted name: formate dehydrogenase
Reaction: formate + NAD+ = CO2 + NADH
Other name(s): formate-NAD+ oxidoreductase; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD+-linked formate dehydrogenase; NAD+-dependent formate dehydrogenase; formate dehydrogenase (NAD+); NAD+-formate dehydrogenase; formate benzyl-viologen oxidoreductase; formic acid dehydrogenase
Systematic name: formate:NAD+ oxidoreductase
Comments: The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-85-7
1.  Davison, D.C. Studies on plant formic dehydrogenase. Biochem. J. 49 (1951) 520–526. [PMID: 14886318]
2.  Quayle, J.R. Formate dehydrogenase. Methods Enzymol. 9 (1966) 360–364.
3.  Jollie, D.R. and Lipscomb, J.D. Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors. J. Biol. Chem. 266 (1991) 21853–21863. [PMID: 1657982]
[EC created 1961 as EC, transferred 2017 to EC]

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