| EC |
1.17.1.9 |
| Accepted name: |
formate dehydrogenase |
| Reaction: |
formate + NAD+ = CO2 + NADH |
| Other name(s): |
formate-NAD+ oxidoreductase; FDH I; FDH II; N-FDH; formic hydrogen-lyase; formate hydrogenlyase; hydrogenlyase; NAD+-linked formate dehydrogenase; NAD+-dependent formate dehydrogenase; formate dehydrogenase (NAD+); NAD+-formate dehydrogenase; formate benzyl-viologen oxidoreductase; formic acid dehydrogenase |
| Systematic name: |
formate:NAD+ oxidoreductase |
| Comments: |
The enzyme from most aerobic organisms is devoid of redox-active centres but that from the proteobacterium Methylosinus trichosporium contains iron-sulfur centres, flavin and a molybdenum centre [3]. Together with EC 1.12.1.2 hydrogen dehydrogenase, forms a system previously known as formate hydrogenlyase. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-85-7 |
| References: |
| 1. |
Davison, D.C. Studies on plant formic dehydrogenase. Biochem. J. 49 (1951) 520–526. [PMID: 14886318] |
| 2. |
Quayle, J.R. Formate dehydrogenase. Methods Enzymol. 9 (1966) 360–364. |
| 3. |
Jollie, D.R. and Lipscomb, J.D. Formate dehydrogenase from Methylosinus trichosporium OB3b. Purification and spectroscopic characterization of the cofactors. J. Biol. Chem. 266 (1991) 21853–21863. [PMID: 1657982] |
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| [EC 1.17.1.9 created 1961 as EC 1.2.1.2, transferred 2017 to EC 1.17.1.9] |
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