The Enzyme Database

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Accepted name: 6-hydroxynicotinate dehydrogenase
Reaction: 6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2
Other name(s): 6-hydroxynicotinic acid hydroxylase; 6-hydroxynicotinic acid dehydrogenase; 6-hydroxynicotinate hydroxylase; 6-hydroxynicotinate:O2 oxidoreductase
Systematic name: 6-hydroxynicotinate:oxygen oxidoreductase
Comments: Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 122191-32-6
1.  Nagel, M. and Andreesen, J.R. Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923. FEMS Microbiol. Lett. 59 (1989) 147–152.
2.  Nagel, M. and Andreesen, J.R. Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini. Arch. Microbiol. 154 (1990) 605–613.
[EC created 2004]

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