| EC |
1.17.3.3 |
| Accepted name: |
6-hydroxynicotinate dehydrogenase |
| Reaction: |
6-hydroxynicotinate + H2O + O2 = 2,6-dihydroxynicotinate + H2O2 |
| Other name(s): |
6-hydroxynicotinic acid hydroxylase; 6-hydroxynicotinic acid dehydrogenase; 6-hydroxynicotinate hydroxylase; 6-hydroxynicotinate:O2 oxidoreductase |
| Systematic name: |
6-hydroxynicotinate:oxygen oxidoreductase |
| Comments: |
Contains [2Fe-2S] iron-sulfur centres, FAD and molybdenum. It also has a catalytically essential, labile selenium that can be removed by reaction with cyanide. In Bacillus niacini, this enzyme is required for growth on nicotinic acid. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 122191-32-6 |
| References: |
| 1. |
Nagel, M. and Andreesen, J.R. Molybdenum-dependent degradation of nicotinic acid by Bacillus sp. DSM 2923. FEMS Microbiol. Lett. 59 (1989) 147–152. |
| 2. |
Nagel, M. and Andreesen, J.R. Purification and characterization of the molybdoenzymes nicotinate dehydrogenase and 6-hydroxynicotinate dehydrogenase from Bacillus niacini. Arch. Microbiol. 154 (1990) 605–613. |
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| [EC 1.17.3.3 created 2004] |
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