ExplorEnz: EC 1.18.1.3

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1.18.1.3

Accepted name:

ferredoxin—NAD⁺ reductase

Reaction:

(1) 2 reduced [2Fe-2S] ferredoxin + NAD⁺ + H⁺ = 2 oxidized [2Fe-2S] ferredoxin + NADH
(2) reduced 2[4Fe-4S] ferredoxin + NAD⁺ + H⁺ = oxidized 2[4Fe-4S] ferredoxin + NADH

Glossary:

ferredoxin

Other name(s):

ferredoxin-nicotinamide adenine dinucleotide reductase; ferredoxin reductase (ambiguous); NAD⁺-ferredoxin reductase; NADH-ferredoxin oxidoreductase; reductase, reduced nicotinamide adenine dinucleotide-ferredoxin; ferredoxin-NAD⁺ reductase; NADH-ferredoxin reductase; NADH₂-ferredoxin oxidoreductase; NADH flavodoxin oxidoreductase; NADH-ferredoxin NAP reductase (component of naphthalene dioxygenase multicomponent enzyme system); ferredoxin-linked NAD⁺ reductase; NADH-ferredoxin TOL reductase (component of toluene dioxygenase); ferredoxin—NAD reductase

Systematic name:

ferredoxin:NAD⁺ oxidoreductase

Comments:

Contains FAD. Reaction (1) is written for a [2Fe-2S] ferredoxin, which is characteristic of some mono- and dioxygenase systems. The alternative reaction (2) is written for a 2[4Fe-4S] ferredoxin, which transfers two electrons, and occurs in metabolism of anaerobic bacteria.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39369-37-4

References:

1.	Jungerman, K., Thauer, R.F., Leimenstoll, G. and Decker, K. Function of reduced pyridine nucleotide-ferredoxin oxidoreductases in saccharolytic Clostridia. Biochim. Biophys. Acta 305 (1973) 268–280. [DOI] [PMID: 4147457]
2.	Haigler, B.E. and Gibson, D.T. Purification and properties of NADH-ferredoxinNAP reductase, a component of naphthalene dioxygenase from Pseudomonas sp. strain NCIB 9816. J. Bacteriol. 172 (1990) 457–464. [DOI] [PMID: 2294092]
3.	Ramachandra, M., Seetharam, R., Emptage, M.H. and Sariaslani, F.S. Purification and characterization of a soybean flour-inducible ferredoxin reductase of Streptomyces griseus. J. Bacteriol. 173 (1991) 7106–7112. [DOI] [PMID: 1938912]
4.	Shaw, J.P. and Harayama, S. Purification and characterisation of the NADH:acceptor reductase component of xylene monooxygenase encoded by the TOL plasmid pWW0 of Pseudomonas putida mt-2. Eur. J. Biochem. 209 (1992) 51–61. [DOI] [PMID: 1327782]

[EC 1.18.1.3 created 1976 as EC 1.6.7.3, transferred 1978 to EC 1.18.1.3, modified 2011]