| EC |
1.2.1.24 |
| Accepted name: |
succinate-semialdehyde dehydrogenase (NAD+) |
| Reaction: |
succinate semialdehyde + NAD+ + H2O = succinate + NADH + 2 H+ |
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For diagram of arginine catabolism, click here and for diagram of the citric acid cycle, click here |
| Other name(s): |
succinate semialdehyde dehydrogenase (NAD+); succinic semialdehyde dehydrogenase (NAD+); succinyl semialdehyde dehydrogenase (NAD+); succinate semialdehyde:NAD+ oxidoreductase |
| Systematic name: |
succinate-semialdehyde:NAD+ oxidoreductase |
| Comments: |
This enzyme participates in the degradation of glutamate and 4-aminobutyrate. It is similar to EC 1.2.1.79 [succinate-semialdehyde dehydrogenase (NADP+)], and EC 1.2.1.16 [succinate-semialdehyde dehydrogenase (NAD(P)+)], but is specific for NAD+. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-95-9 |
| References: |
| 1. |
Albers, R.W. and Koval, G.J. Succinic semialdehyde dehydrogenase : purification and properties of the enzyme from monkey brain. Biochim. Biophys. Acta 52 (1961) 29–35. [DOI] [PMID: 13860092] |
| 2. |
Ryzlak, M.T. and Pietruszko, R. Human brain "high Km" aldehyde dehydrogenase: purification, characterization, and identification as NAD+ -dependent succinic semialdehyde dehydrogenase. Arch. Biochem. Biophys. 266 (1988) 386–396. [DOI] [PMID: 3190233] |
| 3. |
Busch, K.B. and Fromm, H. Plant succinic semialdehyde dehydrogenase. Cloning, purification, localization in mitochondria, and regulation by adenine nucleotides. Plant Physiol. 121 (1999) 589–597. [PMID: 10517851] |
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| [EC 1.2.1.24 created 1972, modified 2010] |
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