| EC |
1.2.1.58 |
| Accepted name: |
phenylglyoxylate dehydrogenase (acylating) |
| Reaction: |
phenylglyoxylate + NAD+ + CoA = benzoyl-S-CoA + CO2 + NADH |
| Systematic name: |
phenylglyoxylate:NAD+ oxidoreductase |
| Comments: |
Requires thiamine diphosphate as cofactor. The enzyme from the denitrifying bacterium Azoarcus evansii is specific for phenylglyoxylate. 2-Oxoisovalerate is oxidized at 15% of the rate for phenylglyoxylate. Also reduces viologen dyes. Contains iron-sulfur centres and FAD. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 205510-78-7 |
| References: |
| 1. |
Hirsch, W., Schägger, H. and Fuchs, G. Phenylglyoxylate:NAD+ oxidoreductase (CoA benzoylating), a new enzyme of anaerobic phenylalanine metabolism in the denitrifying bacterium Axoarcus evansii. Eur. J. Biochem. 251 (1998) 907–915. [DOI] [PMID: 9490067] |
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| [EC 1.2.1.58 created 1999] |
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