The Enzyme Database

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Accepted name: D-glyceraldehyde dehydrogenase (NADP+)
Reaction: D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+
Other name(s): glyceraldehyde dehydrogenase; GADH
Systematic name: D-glyceraldehyde:NADP+ oxidoreductase
Comments: The enzyme from the archaea Thermoplasma acidophilum and Picrophilus torridus is involved in the non-phosphorylative Entner-Doudoroff pathway. cf. EC, glyceraldehyde dehydrogenase (FAD-containing).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Jung, J.H. and Lee, S.B. Identification and characterization of Thermoplasma acidophilum glyceraldehyde dehydrogenase: a new class of NADP+-specific aldehyde dehydrogenase. Biochem. J. 397 (2006) 131–138. [DOI] [PMID: 16566751]
2.  Reher, M. and Schonheit, P. Glyceraldehyde dehydrogenases from the thermoacidophilic euryarchaeota Picrophilus torridus and Thermoplasma acidophilum, key enzymes of the non-phosphorylative Entner-Doudoroff pathway, constitute a novel enzyme family within the aldehyde dehydrogenase superfamily. FEBS Lett. 580 (2006) 1198–1204. [DOI] [PMID: 16458304]
[EC created 2014]

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