ExplorEnz: EC 1.2.1.99

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1.2.1.99

Accepted name:

4-(γ-glutamylamino)butanal dehydrogenase

Reaction:

4-(γ-L-glutamylamino)butanal + NAD(P)⁺ + H₂O = 4-(γ-L-glutamylamino)butanoate + NAD(P)H + H⁺

Other name(s):

puuC (gene name)

Systematic name:

4-(γ-L-glutamylamino)butanal:NAD(P)⁺ oxidoreductase

Comments:

The enzyme, characterized from the bacterium Escherichia coli, is involved in a putrescine catabolic pathway. It has a broad substrate range, and can also catalyse the activities of EC 1.2.1.19, aminobutyraldehyde dehydrogenase, and EC 1.2.1.24, succinate-semialdehyde dehydrogenase (NAD⁺).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Kurihara, S., Oda, S., Kato, K., Kim, H.G., Koyanagi, T., Kumagai, H. and Suzuki, H. A novel putrescine utilization pathway involves γ-glutamylated intermediates of Escherichia coli K-12. J. Biol. Chem. 280 (2005) 4602–4608. [DOI] [PMID: 15590624]
2.	Jo, J.E., Mohan Raj, S., Rathnasingh, C., Selvakumar, E., Jung, W.C. and Park, S. Cloning, expression, and characterization of an aldehyde dehydrogenase from Escherichia coli K-12 that utilizes 3-hydroxypropionaldehyde as a substrate. Appl. Microbiol. Biotechnol. 81 (2008) 51–60. [DOI] [PMID: 18668238]
3.	Schneider, B.L. and Reitzer, L. Pathway and enzyme redundancy in putrescine catabolism in Escherichia coli. J. Bacteriol. 194 (2012) 4080–4088. [DOI] [PMID: 22636776]

[EC 1.2.1.99 created 2017]