The Enzyme Database

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Accepted name: phosphonate dehydrogenase
Reaction: phosphonate + NAD+ + H2O = phosphate + NADH + H+
Other name(s): NAD:phosphite oxidoreductase; phosphite dehydrogenase
Systematic name: phosphonate:NAD+ oxidoreductase
Comments: NADP+ is a poor substitute for NAD+ in the enzyme from Pseudomonas stutzeri WM88.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9031-35-0
1.  Costas, A.M.G., White, A.K. and Metcalf, W.W. Purification and characterization of a novel phosphorus-oxidizing enzyme from Pseudomonas stutzeri WM88. J. Biol. Chem. 276 (2001) 17429–17436. [DOI] [PMID: 11278981]
2.  Vrtis, J.M., White, A.K., Metcalf, W.W. and van der Donk, W.A. Phosphite dehydrogenase: An unusual phosphoryl transfer reaction. J. Am. Chem. Soc. 123 (2001) 2672–2673. [PMID: 11456941]
[EC created 2001]

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