EC |
1.20.4.2 |
Accepted name: |
methylarsonate reductase |
Reaction: |
methylarsonate + 2 glutathione = methylarsonite + glutathione disulfide + H2O |
Glossary: |
methylarsonite = methylarsonous acid
cacodylic acid = dimethylarsinic acid |
Other name(s): |
MMA(V) reductase |
Systematic name: |
methylarsonate:glutathione oxidoreductase |
Comments: |
The product, methylarsonite, is biologically methylated by EC 2.1.1.137, arsenite methyltransferase, to form cacodylic acid. |
References: |
1. |
Zakharyan, R.A. and Aposhian, H.V. Enzymatic reduction of arsenic compounds in mammalian systems: the rate-limiting enzyme of rabbit liver arsenic biotransformation is MMA(V) reductase. Chem. Res. Toxicol. 12 (1999) 1278–1283. [PMID: 10604879] |
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[EC 1.20.4.2 created 2000 as EC 1.97.1.7, transferred 2001 to EC 1.20.4.2, modified 2003] |
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