ExplorEnz: EC 1.21.1.1

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1.21.1.1

Accepted name:

iodotyrosine deiodinase

Reaction:

L-tyrosine + 2 NADP⁺ + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH + 2 H⁺ (overall reaction)
(1a) L-tyrosine + NADP⁺ + iodide = 3-iodo-L-tyrosine + NADPH + H⁺
(1b) 3-iodo-L-tyrosine + NADP⁺ + iodide = 3,5-diiodo-L-tyrosine + NADPH + H⁺

Other name(s):

iodotyrosine dehalogenase 1; DEHAL1

Systematic name:

L-tyrosine,iodide:NADP⁺ oxidoreductase (iodinating)

Comments:

The enzyme activity has only been demonstrated in the direction of 3-deiodination. Present in a transmembrane flavoprotein. Requires FMN.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Rosenberg, I.N. Purification of iodotyrosine deiodinase from bovine thyroid. Metabolism 19 (1970) 785–798. [DOI] [PMID: 4394169]
2.	Gnidehou, S., Caillou, B., Talbot, M., Ohayon, R., Kaniewski, J., Noel-Hudson, M.S., Morand, S., Agnangji, D., Sezan, A., Courtin, F., Virion, A. and Dupuy, C. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. FASEB J. 18 (2004) 1574–1576. [DOI] [PMID: 15289438]
3.	Friedman, J.E., Watson, J.A., Jr., Lam, D.W. and Rokita, S.E. Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. J. Biol. Chem. 281 (2006) 2812–2819. [DOI] [PMID: 16316988]
4.	Thomas, S.R., McTamney, P.M., Adler, J.M., Laronde-Leblanc, N. and Rokita, S.E. Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands. J. Biol. Chem. 284 (2009) 19659–19667. [DOI] [PMID: 19436071]

[EC 1.21.1.1 created 2010 as EC 1.22.1.1, transferred 2015 to EC 1.21.1.1]