ExplorEnz: EC 1.21.3.1

Your query returned 1 entry. Printable version

1.21.3.1

Accepted name:

isopenicillin-N synthase

Reaction:

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O₂ = isopenicillin N + 2 H₂O

For diagram of penicillin-N and deacetoxycephalosporin-C biosynthesis, click here and for possible mechanism of reaction, click here

Other name(s):

isopenicillin N synthetase

Systematic name:

N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)

Comments:

Forms part of the penicillin biosynthesis pathway (for pathway, click here).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 78642-31-6

References:

1.	Huffman, G.W., Gesellchen, P.D., Turner, J.R., Rothenberger, R.B., Osborne, H.E., Miller, F.D., Chapman, J.L. and Queener, S.W. Substrate specificity of isopenicillin N synthase. J. Med. Chem. 35 (1992) 1897–1914. [PMID: 1588566]
2.	Roach, P.L., Clifton, I.J., Fulop, V., Harlos, K., Barton, G.J., Hajdu, J., Andersson, I., Schofield, C.J. and Baldwin, J.E. Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature 375 (1995) 700–704. [DOI] [PMID: 7791906]

[EC 1.21.3.1 created 2002]