The Enzyme Database

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Accepted name: columbamine oxidase
Reaction: 2 columbamine + O2 = 2 berberine + 2 H2O
For diagram of columbamine, palmatine and corydaline biosynthesis, click here
Other name(s): berberine synthase
Systematic name: columbamine:oxygen oxidoreductase (cyclizing)
Comments: An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 95329-18-3
1.  Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201–202.
[EC created 1989 as EC, transferred 2002 to EC]

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