| EC |
1.21.3.2 |
| Accepted name: |
columbamine oxidase |
| Reaction: |
2 columbamine + O2 = 2 berberine + 2 H2O |
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For diagram of columbamine, palmatine and corydaline biosynthesis, click here |
| Other name(s): |
berberine synthase |
| Systematic name: |
columbamine:oxygen oxidoreductase (cyclizing) |
| Comments: |
An iron protein. Oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 95329-18-3 |
| References: |
| 1. |
Rueffer, M. and Zenk, M.H. Berberine synthesis, the methylenedioxy group forming enzyme in berberine synthesis. Tetrahedron Lett. 26 (1985) 201–202. |
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| [EC 1.21.3.2 created 1989 as EC 1.1.3.26, transferred 2002 to EC 1.21.3.2] |
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