ExplorEnz: EC 1.3.1.117

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1.3.1.117

Accepted name:

hydroxycinnamoyl-CoA reductase

Reaction:

(1) dihydro-4-coumaroyl-CoA + NADP⁺ = trans-4-coumaroyl-CoA + NADPH + H⁺
(2) dihydroferuloyl-CoA + NADP⁺ = trans-feruloyl-CoA + NADPH + H⁺

For diagram of phloretin biosynthesis, click here

Glossary:

trans-4-coumaroyl-CoA = (E)-3-(4-hydroxyphenyl)prop-2-enoyl-CoA
trans-feruloyl-CoA = (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl-CoA
dihydro-4-coumaroyl-CoA = 3-(4-hydroxyphenyl)propanoyl-CoA
dihydroferuloyl-CoA = 3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA

Other name(s):

MdHCDBR; hydroxycinnamoyl-CoA double bond reductase

Systematic name:

dihydro-4-coumaroyl-CoA:NADP⁺ 2,3-oxidoreductase

Comments:

Isolated from Malus X domestica (apple). Involved in dihydrochalcone biosynthesis.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Ibdah, M., Berim, A., Martens, S., Valderrama, A.L.H., Palmieri, L., Lewinsohn, E. and Gang, D.R. Identification and cloning of an NADPH-dependant hydroxycinnamoyl-CoA double bond reductase involved in dihydrochalcone formation in Malus X domestica Borkh. Phytochemistry 107 (2014) 24-31. [DOI] [PMID: 25152451]

[EC 1.3.1.117 created 2018]