The Enzyme Database

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Accepted name: 2-epi-5-epi-valiolone dehydrogenase
Reaction: 2-epi-5-epi-valiolone + NAD+ = demethylgadusol + NADH + H+
Glossary: 2-epi-5-epi-valiolone = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one
demethylgadusol = (4R,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohex-2-en-1-one
Other name(s): gadusol synthase
Systematic name: 2-epi-5-epi-valiolone:NAD+ 2,3-oxidoreductase
Comments: The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC, demethylgadusol O-methyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Osborn, A.R., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T. and Mahmud, T. De novo synthesis of a sunscreen compound in vertebrates. Elife 4 (2015) . [DOI] [PMID: 25965179]
[EC created 2023]

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