| EC |
1.3.1.2 |
| Accepted name: |
dihydropyrimidine dehydrogenase (NADP+) |
| Reaction: |
5,6-dihydrouracil + NADP+ = uracil + NADPH + H+ |
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For diagram of pyrimidine catabolism, click here |
| Other name(s): |
dihydrothymine dehydrogenase; dihydrouracil dehydrogenase (NADP+); 4,5-dihydrothymine: oxidoreductase; DPD; DHPDH; dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate); DHU dehydrogenase; hydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase (NADP) |
| Systematic name: |
5,6-dihydrouracil:NADP+ 5-oxidoreductase |
| Comments: |
Also acts on dihydrothymine. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9029-01-0 |
| References: |
| 1. |
Fritzson, P. Properties and assay of dihydrouracil dehydrogenase of rat liver. J. Biol. Chem. 235 (1960) 719–725. [PMID: 13825299] |
| 2. |
Shiotani, T. and Weber, G. Purification and properties of dihydrothymine dehydrogenase from rat liver. J. Biol. Chem. 256 (1981) 219–224. [PMID: 7451435] |
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| [EC 1.3.1.2 created 1961, modified 1986] |
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