EC |
1.3.1.45 |
Accepted name: |
2′-hydroxyisoflavone reductase |
Reaction: |
vestitone + NADP+ = 2′-hydroxyformononetin + NADPH + H+ |
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For diagram of the biosynthesis of formononetin and derivatives, click here |
Other name(s): |
NADPH:2′-hydroxyisoflavone oxidoreductase; isoflavone reductase; 2′,7-dihydroxy-4′,5′-methylenedioxyisoflavone reductase |
Systematic name: |
vestitone:NADP+ oxidoreductase |
Comments: |
In the reverse reaction, a 2′-hydroxyisoflavone is reduced to an isoflavanone; 2′-hydroxypseudobaptigenin also acts. Involved in the biosynthesis of the pterocarpin phytoalexins medicarpin and maackiain. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 128449-69-4 |
References: |
1. |
Tiemann, K., Hinderer, W. and Barz, W. Isolation of NADPH:isoflavone oxidoreductase, a new enzyme of pterocarpan biosynthesis in cell suspensions of Cicer arietinum. FEBS Lett. 213 (1987) 324–328. |
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[EC 1.3.1.45 created 1990] |
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