EC |
1.3.1.51 |
Accepted name: |
2′-hydroxydaidzein reductase |
Reaction: |
2′-hydroxy-2,3-dihydrodaidzein + NADP+ = 2′-hydroxydaidzein + NADPH + H+ |
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For diagram of glyceollin biosynthesis (part 1), click here |
Other name(s): |
NADPH:2′-hydroxydaidzein oxidoreductase; HDR; 2′-hydroxydihydrodaidzein:NADP+ 2′-oxidoreductase |
Systematic name: |
2′-hydroxy-2,3-dihydrodaidzein:NADP+ 2′-oxidoreductase |
Comments: |
In the reverse reaction, the 2′-hydroxyisoflavone (2′-hydroxydaidzein) is reduced to an isoflavanone. Also acts on 2′-hydroxyformononetin and to a small extent on 2′-hydroxygenistein. Involved in the biosynthesis of the phytoalexin glyceollin. The isoflavones biochanin A, daidzein and genestein as well as the flavonoids apigenin, kaempferol and quercetin do not act as substrates. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 126125-01-7 |
References: |
1. |
Fischer, D., Ebenau-Jehle, C. and Grisebach, H. Phytoalexin synthesis in soybean: purification and characterization of NADPH:2′-hydroxydaidzein oxidoreductase from elicitor-challenged soybean cell cultures. Arch. Biochem. Biophys. 276 (1990) 390–395. [DOI] [PMID: 2306102] |
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[EC 1.3.1.51 created 1992, modified 2004] |
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