| EC |
1.3.1.54 |
| Accepted name: |
precorrin-6A reductase |
| Reaction: |
precorrin-6B + NADP+ = precorrin-6A + NADPH + H+ |
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For diagram of corrin biosynthesis (part 3), click here |
| Other name(s): |
precorrin-6X reductase; precorrin-6Y:NADP+ oxidoreductase; CobK |
| Systematic name: |
precorrin-6B:NADP+ oxidoreductase |
| Comments: |
The enzyme, which participates in the aerobic (late cobalt insertion) pathway of adenosylcobalamin biosynthesis, catalyses the reduction of the double bond between C-18 and C-19 of precorrin-6A. See EC 1.3.1.106, cobalt-precorrin-6A reductase, for the corresponding enzyme that participates in the anaerobic cobalamin biosynthesis pathway. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 137573-72-9 |
| References: |
| 1. |
Blanche, F., Thibaut, D., Famechon, A., Debussche, L., Cameron, B. and Crouzet, J. Precorrin-6X reductase from Pseudomonas denitrificans: purification and characterization of the enzyme and identification of the structural gene. J. Bacteriol. 174 (1992) 1036–1042. [DOI] [PMID: 1732193] |
| 2. |
Warren, M.J., Raux, E., Schubert, H.L. and Escalante-Semerena, J.C. The biosynthesis of adenosylcobalamin (vitamin B12). Nat. Prod. Rep. 19 (2002) 390–412. [PMID: 12195810] |
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| [EC 1.3.1.54 created 1999, modified 2004] |
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