The Enzyme Database

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Accepted name: Δ24(241)-sterol reductase
Reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3β-ol + NADPH + H+
For diagram of sterol-sidechain modification, click here
Other name(s): sterol Δ24(28)-methylene reductase; sterol Δ24(28)-reductase
Systematic name: ergosterol:NADP+ Δ24(241)-oxidoreductase
Comments: Acts on a range of steroids with a 24(241)-double bond.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Neal, W.D. and Parks, L.W. Sterol 24(28) methylene reductase in Saccharomyces cerevisiae. J. Bacteriol. 129 (1977) 1375–1378. [PMID: 14922]
2.  Zweytick, D., Hrastnik, C. , Kohlwein. S.D. and Daum, G. Biochemical characterization and subcellular localization of the sterol C-24(28) reductase, erg4p, from the yeast Saccharomyces cerevisiae. FEBS Lett. 470 (2000) 83–87. [DOI] [PMID: 10722850]
[EC created 2001, modified 2002]

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