ExplorEnz: EC 1.3.1.72

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1.3.1.72

Accepted name:

Δ²⁴-sterol reductase

Reaction:

5α-cholest-7-en-3β-ol + NADP⁺ = 5α-cholesta-7,24-dien-3β-ol + NADPH + H⁺

For diagram of sterol-sidechain modification, click here

Glossary:

desmosterol = cholesta-5,24-dien-3β-ol
lanosterol = 4,4,14-trimethyl-5α-cholesta-8,24-dien-3β-ol
zymostrol = 5α-cholesta-8,24-dien-3β-ol

Other name(s):

lanosterol Δ²⁴-reductase

Systematic name:

sterol:NADP⁺ Δ²⁴-oxidoreductase

Comments:

Acts on a range of steroids with a 24(25)-double bond, including lanosterol, desmosterol and zymosterol.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9033-57-2

References:

1.	Bae, S.H. and Paik, Y.K. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol Δ²⁴-reductase. Biochem. J. 326 (1997) 609–616. [PMID: 9291139]

[EC 1.3.1.72 created 2001]