| EC |
1.3.1.79 |
| Accepted name: |
arogenate dehydrogenase [NAD(P)+] |
| Reaction: |
L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2 |
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For diagram of phenylalanine and tyrosine biosynthesis, click here |
| Glossary: |
L-arogenate = 1-[(2S)-2-amino-2-carboxyethyl]-4-hydroxycyclohexa-2,5-diene-1-carboxylate |
| Other name(s): |
arogenic dehydrogenase (ambiguous); cyclohexadienyl dehydrogenase; pretyrosine dehydrogenase (ambiguous) |
| Systematic name: |
L-arogenate:NAD(P)+ oxidoreductase (decarboxylating) |
| Comments: |
Arogenate dehydrogenases may utilize NAD+ (EC 1.3.1.43), NADP+ (EC 1.3.1.78), or both (EC 1.3.1.79). Enzymes that can utilize both cofactors have been reported from some Proteobacteria, including Burkholderia caryophylli, Burkholderia cepacia, Pseudomonas marginata and Delftia acidovorans. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 64295-75-6 |
| References: |
| 1. |
Byng, G.S., Whitaker, R.J., Gherna, R.L. and Jensen, R.A. Variable enzymological patterning in tyrosine biosynthesis as a means of determining natural relatedness among the Pseudomonadaceae. J. Bacteriol. 144 (1980) 247–257. [PMID: 7419490] |
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| [EC 1.3.1.79 created 2005] |
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