ExplorEnz: EC 1.3.1.81

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1.3.1.81

Accepted name:

(+)-pulegone reductase

Reaction:

(1) (–)-menthone + NADP⁺ = (+)-pulegone + NADPH + H⁺
(2) (+)-isomenthone + NADP⁺ = (+)-pulegone + NADPH + H⁺

For diagram of menthol biosynthesis, click here

Systematic name:

(–)-menthone:NADP⁺ oxidoreductase

Comments:

NADH cannot replace NADPH as reductant. The Δ^8,9-double bond of (+)-cis-isopulegone and the Δ^1,2-double bond of (±)-piperitone are not substrates. The enzyme from peppermint (Mentha × piperita) converts (+)-pulegone into both (–)-menthone and (+)-isomenthone at a ratio of 70:30 for native enzyme but it does not catalyse the reverse reaction. This enzyme is a member of the medium-chain dehydrogenase/reductase superfamily.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Ringer, K.L., McConkey, M.E., Davis, E.M., Rushing, G.W. and Croteau, R. Monoterpene double-bond reductases of the (-)-menthol biosynthetic pathway: isolation and characterization of cDNAs encoding (-)-isopiperitenone reductase and (+)-pulegone reductase of peppermint. Arch. Biochem. Biophys. 418 (2003) 80–92. [DOI] [PMID: 13679086]

[EC 1.3.1.81 created 2008]