ExplorEnz: EC 1.3.1.90

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1.3.1.90

Accepted name:

tRNA-dihydrouridine^20a/20b synthase [NAD(P)⁺]

Reaction:

(1) 5,6-dihydrouracil^20a in tRNA + NAD(P)⁺ = uracil^20a in tRNA + NAD(P)H + H⁺
(2) 5,6-dihydrouracil^20b in tRNA + NAD(P)⁺ = uracil^20b in tRNA + NAD(P)H + H⁺

Other name(s):

Dus4p

Systematic name:

tRNA-5,6-dihydrouracil^20a/20b:NAD(P)⁺ oxidoreductase

Comments:

A flavoenzyme. The enzyme specifically modifies uracil^20a and uracil^20b in tRNA.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Xing, F., Hiley, S.L., Hughes, T.R. and Phizicky, E.M. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J. Biol. Chem. 279 (2004) 17850–17860. [DOI] [PMID: 14970222]

[EC 1.3.1.90 created 2011]