The Enzyme Database

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Accepted name: 15-cis-phytoene desaturase
Reaction: 15-cis-phytoene + 2 plastoquinone = 9,15,9′-tricis-ζ-carotene + 2 plastoquinol (overall reaction)
(1a) 15-cis-phytoene + plastoquinone = 15,9′-dicis-phytofluene + plastoquinol
(1b) 15,9′-dicis-phytofluene + plastoquinone = 9,15,9′-tricis-ζ-carotene + plastoquinol
For diagram of plant and cyanobacteria carotenoid biosynthesis, click here
Other name(s): phytoene desaturase (ambiguous); PDS; plant-type phytoene desaturase
Systematic name: 15-cis-phytoene:plastoquinone oxidoreductase
Comments: This enzyme is involved in carotenoid biosynthesis in plants and cyanobacteria. The enzyme from Synechococcus can also use NAD+ and NADP+ as electron acceptor under anaerobic conditions. The enzyme from Gentiana lutea shows no activity with NAD+ or NADP+ [1].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB
1.  Breitenbach, J., Zhu, C. and Sandmann, G. Bleaching herbicide norflurazon inhibits phytoene desaturase by competition with the cofactors. J. Agric. Food Chem. 49 (2001) 5270–5272. [DOI] [PMID: 11714315]
2.  Schneider, C., Boger, P. and Sandmann, G. Phytoene desaturase: heterologous expression in an active state, purification, and biochemical properties. Protein Expr. Purif. 10 (1997) 175–179. [DOI] [PMID: 9226712]
3.  Fraser, P.D., Linden, H. and Sandmann, G. Purification and reactivation of recombinant Synechococcus phytoene desaturase from an overexpressing strain of Escherichia coli. Biochem. J. 291 (1993) 687–692. [PMID: 8489496]
4.  Breitenbach, J. and Sandmann, G. ζ-Carotene cis isomers as products and substrates in the plant poly-cis carotenoid biosynthetic pathway to lycopene. Planta 220 (2005) 785–793. [DOI] [PMID: 15503129]
[EC created 2011]

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