ExplorEnz: EC 1.3.8.16

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1.3.8.16

Accepted name:

2-amino-4-deoxychorismate dehydrogenase

Reaction:

(2S)-2-amino-4-deoxychorismate + FMN = 3-(1-carboxyvinyloxy)anthranilate + FMNH₂

For diagram of enediyne antitumour antibiotic biosynthesis, click here

Glossary:

(2S)-2-amino-4-deoxychorismate = (2S,3S)-3-(1-carboxyvinyloxy)-2,3-dihydroanthranilate
3-enolpyruvoylanthranilate = 3-(1-carboxyvinyloxy)anthranilate

Other name(s):

ADIC dehydrogenase; 2-amino-2-deoxyisochorismate dehydrogenase; SgcG

Systematic name:

(2S)-2-amino-4-deoxychorismate:FMN oxidoreductase

Comments:

The sequential action of EC 2.6.1.86, 2-amino-4-deoxychorismate synthase and this enzyme leads to the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027 [1,2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Van Lanen, S.G., Lin, S. and Shen, B. Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism. Proc. Natl. Acad. Sci. USA 105 (2008) 494–499. [DOI] [PMID: 18182490]
2.	Yu, L., Mah, S., Otani, T. and Dedon, P. The benzoxazolinate of C-1027 confers intercalative DNA binding. J. Am. Chem. Soc. 117 (1995) 8877–8878. [DOI]

[EC 1.3.8.16 created 2008 as 1.3.99.24, transferred 2020 to EC 1.3.8.16.]