| EC |
1.3.8.3 |
| Accepted name: |
(R)-benzylsuccinyl-CoA dehydrogenase |
| Reaction: |
(R)-2-benzylsuccinyl-CoA + electron-transfer flavoprotein = (E)-2-benzylidenesuccinyl-CoA + reduced electron-transfer flavoprotein |
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For diagram of anaerobic toluene catabolism, click here |
| Other name(s): |
BbsG; (R)-benzylsuccinyl-CoA:(acceptor) oxidoreductase |
| Systematic name: |
(R)-benzylsuccinyl-CoA:electron transfer flavoprotein oxidoreductase |
| Comments: |
Contains a tightly-bound FAD cofactor. Unlike other acyl-CoA dehydrogenases, this enzyme exhibits high substrate- and enantiomer specificity; it is highly specific for (R)-benzylsuccinyl-CoA and is inhibited by (S)-benzylsuccinyl-CoA. Forms the third step in the anaerobic toluene metabolic pathway in Thauera aromatica. Ferricenium ion is an effective artificial electron acceptor. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc |
| References: |
| 1. |
Leutwein, C. and Heider, J. Anaerobic toluene-catabolic pathway in denitrifying Thauera aromatica: activation and β-oxidation of the first intermediate, (R)-(+)-benzylsuccinate. Microbiology 145 (1999) 3265–3271. [DOI] [PMID: 10589736] |
| 2. |
Leutwein, C. and Heider, J. (R)-Benzylsuccinyl-CoA dehydrogenase of Thauera aromatica, an enzyme of the anaerobic toluene catabolic pathway. Arch. Microbiol. 178 (2002) 517–524. [DOI] [PMID: 12420174] |
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| [EC 1.3.8.3 created 2003 as EC 1.3.99.21, transferred 2012 to EC 1.3.8.3] |
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