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Your query returned 1 entry. 
Printable version
| EC | 1.3.8.6 | ||||||||
| Accepted name: | glutaryl-CoA dehydrogenase (ETF) | ||||||||
| Reaction: | glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein (overall reaction) (1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein (1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO2 |
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| For diagram of Benzoyl-CoA catabolism, click here | |||||||||
| Glossary: | (E)-glutaconyl-CoA = (2E)-4-carboxybut-2-enoyl-CoA crotonyl-CoA = (E)-but-2-enoyl-CoA |
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| Other name(s): | glutaryl coenzyme A dehydrogenase; glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating); glutaryl-CoA dehydrogenase | ||||||||
| Systematic name: | glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating) | ||||||||
| Comments: | Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 7.2.4.5, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA [EC 1.3.99.32, glutaryl-CoA dehydrogenase (acceptor)]. | ||||||||
| Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37255-38-2 | ||||||||
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