ExplorEnz: EC 1.3.98.4

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1.3.98.4

Accepted name:

5a,11a-dehydrotetracycline reductase

Reaction:

tetracycline + oxidized coenzyme F₄₂₀ = 5a,11a-dehydrotetracycline + reduced coenzyme F₄₂₀

For diagram of tetracycline biosynthesis, click here

Other name(s):

oxyR (gene name); 12-dehydrotetracycline dehydrogenase; dehydrooxytetracycline dehydrogenase; 12-dehydrotetracycline reductase

Systematic name:

tetracycline:coenzyme F₄₂₀ dehydrogenase

Comments:

The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	McCormick, J.R.D., Hirsch, U., Sjolander, N.O. and Doerschuk, A.P. Cosynthesis of tetracyclines by pairs of Streptomyces aureofaciens mutants. J. Am. Chem. Soc. 82 (1960) 5006–5007.
2.	Miller, P.A., Sjolander, N.O., Nalesnyk, S., Arnold, N., Johnson, S., Doerschuk, A.P. and McCormick, J.R.D. Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens. J. Am. Chem. Soc. 82 (1960) 5002–5003.
3.	McCormick, J.R.D. and Morton, G.O. Identity of cosynthetic factor I of Streptomyces aureofaciens and fragment FO from coenzyme F₄₂₀ of Methanobacterium species. J. Am. Chem. Soc. 104 (1982) 4014–4015.
4.	Wang, P., Bashiri, G., Gao, X., Sawaya, M.R. and Tang, Y. Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. J. Am. Chem. Soc. 135 (2013) 7138–7141. [DOI] [PMID: 23621493]

[EC 1.3.98.4 created 2016]