| EC |
1.3.99.16 |
| Accepted name: |
isoquinoline 1-oxidoreductase |
| Reaction: |
isoquinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor |
| Systematic name: |
isoquinoline:acceptor 1-oxidoreductase (hydroxylating) |
| Comments: |
The enzyme from Pseudomonas diminuta is specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline. Electron acceptors include 1,2-benzoquinone, cytochrome c, ferricyanide, iodonitrotetrazolium chloride, nitroblue tetrazolium, Meldola blue and phenazine methosulfate. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 155948-73-5 |
| References: |
| 1. |
Lehmann, M., Tshisuaka, B., Fetzner, S., Roger, P. and Lingens, F. Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase. J. Biol. Chem. 269 (1994) 11254–11260. [PMID: 8157655] |
| 2. |
Lehmann, M., Tshisuaka, B., Fetzner, S. and Lingens, F. Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases. J. Biol. Chem. 270 (1995) 14420–14429. [DOI] [PMID: 7782304] |
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| [EC 1.3.99.16 created 1999] |
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