ExplorEnz: EC 1.3.99.33

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1.3.99.33

Accepted name:

urocanate reductase

Reaction:

dihydrourocanate + acceptor = urocanate + reduced acceptor

For diagram of histidine catabolism, click here

Glossary:

urocanate = 3-(1H-imidazol-4-yl)prop-2-enoate
dihydrourocanate = 3-(1H-imidazol-4-yl)propanoate

Other name(s):

urdA (gene name)

Systematic name:

dihydrourocanate:acceptor oxidoreductase

Comments:

The enzyme from the bacterium Shewanella oneidensis MR-1 contains a noncovalently-bound FAD and a covalently-bound FMN. It functions as part of an anaerobic electron transfer chain that utilizes urocanate as the terminal electron acceptor. The activity has been demonstrated with the artificial donor reduced methyl viologen.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Bogachev, A.V., Bertsova, Y.V., Bloch, D.A. and Verkhovsky, M.I. Urocanate reductase: identification of a novel anaerobic respiratory pathway in Shewanella oneidensis MR-1. Mol. Microbiol. 86 (2012) 1452–1463. [DOI] [PMID: 23078170]

[EC 1.3.99.33 created 2013]