The Enzyme Database

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Accepted name: 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase
Reaction: 3-(methylsulfanyl)propanoyl-CoA + acceptor = 3-(methylsulfanyl)acryloyl-CoA + reduced acceptor
Other name(s): dmdC (gene name)
Systematic name: 3-(methylsulfanyl)propanoyl-CoA:acceptor 2-oxidoreductase
Comments: The enzyme, found in marine bacteria, participates in a 3-(methylsulfanyl)propanoate degradation pathway. Based on similar enzymes, the in vivo electron acceptor is likely electron-transfer flavoprotein (ETF).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Reisch, C.R., Stoudemayer, M.J., Varaljay, V.A., Amster, I.J., Moran, M.A. and Whitman, W.B. Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria. Nature 473 (2011) 208–211. [DOI] [PMID: 21562561]
2.  Bullock, H.A., Luo, H. and Whitman, W.B. Evolution of dimethylsulfoniopropionate metabolism in marine phytoplankton and bacteria. Front. Microbiol. 8:637 (2017). [DOI] [PMID: 28469605]
3.  Shao, X., Cao, H.Y., Zhao, F., Peng, M., Wang, P., Li, C.Y., Shi, W.L., Wei, T.D., Yuan, Z., Zhang, X.H., Chen, X.L., Todd, J.D. and Zhang, Y.Z. Mechanistic insight into 3-methylmercaptopropionate metabolism and kinetical regulation of demethylation pathway in marine dimethylsulfoniopropionate-catabolizing bacteria. Mol. Microbiol. 111 (2019) 1057–1073. [DOI] [PMID: 30677184]
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