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Your query returned 1 entry. Printable version
EC | 1.4.1.18 | ||||||||
Accepted name: | lysine 6-dehydrogenase | ||||||||
Reaction: | L-lysine + NAD+ = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction) (1a) L-lysine + NAD+ + H2O = (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3 (1b) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) |
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For diagram of reaction, click here and for diagram of L-lysine synthesis, click here | |||||||||
Glossary: | (S)-2-amino-6-oxohexanoate = L-2-aminoadipate 6-semialdehyde = L-allysine L-1-piperideine 6-carboxylate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate = (S)-1,6-didehydropiperidine-2-carboxylate |
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Other name(s): | L-lysine ε-dehydrogenase; L-lysine 6-dehydrogenase; LysDH | ||||||||
Systematic name: | L-lysine:NAD+ 6-oxidoreductase (deaminating) | ||||||||
Comments: | The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly. While the enzyme from Agrobacterium tumefaciens can use only NAD+, that from the thermophilic bacterium Geobacillus stearothermophilus can also use NADP+, but more slowly [1,4]. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 89400-30-6 | ||||||||
References: |
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