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Your query returned 1 entry. Printable version
EC | 1.4.1.21 | ||||||||||||||||
Accepted name: | aspartate dehydrogenase | ||||||||||||||||
Reaction: | L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H + H+ (overall reaction) (1a) L-aspartate + NAD(P)+ = 2-iminosuccinate + NAD(P)H + H+ (1b) 2-iminosuccinate + H2O = oxaloacetate + NH3 (spontaneous) |
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Other name(s): | AspDH; NAD-dependent aspartate dehydrogenase; NADH2-dependent aspartate dehydrogenase; NADP+-dependent aspartate dehydrogenase; nadX (gene name); L-aspartate:NAD(P)+ oxidoreductase (deaminating) | ||||||||||||||||
Systematic name: | L-aspartate:NAD(P)+ oxidoreductase (2-iminosuccinate-forming) | ||||||||||||||||
Comments: | The enzyme is strictly specific for L-aspartate as substrate. It produces the unstable compound 2-iminosuccinate, which, in the presence of water, hydrolyses spontaneously to form oxaloacetate. The enzyme from some archaea and thermophilic bacteria is likely to transfer 2-iminosuccinate directly to EC 2.5.1.72, quinolinate synthase, preventing its hydrolysis and enabling the de novo biosynthesis of NAD+. | ||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37278-97-0 | ||||||||||||||||
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