ExplorEnz: EC 1.4.3.19

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1.4.3.19

Accepted name:

glycine oxidase

Reaction:

glycine + H₂O + O₂ = glyoxylate + NH₃ + H₂O₂ (overall reaction)
(1a) glycine + O₂ = 2-iminoacetate + H₂O₂
(1b) 2-iminoacetate + H₂O = glyoxylate + NH₃

For diagram of thiamine diphosphate biosynthesis, click here

Systematic name:

glycine:oxygen oxidoreductase (deaminating)

Comments:

A flavoenzyme containing non-covalently bound FAD. The enzyme from Bacillus subtilis is active with glycine, sarcosine, N-ethylglycine, D-alanine, D-α-aminobutyrate, D-proline, D-pipecolate and N-methyl-D-alanine. It differs from EC 1.4.3.3, D-amino-acid oxidase, due to its activity on sarcosine and D-pipecolate. The intermediate 2-iminoacetate is used directly by EC 2.8.1.10, thiazole synthase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 39307-16-9

References:

1.	Job, V., Marcone, G.L., Pilone, M.S. and Pollegioni, L. Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein. J. Biol. Chem. 277 (2002) 6985–6993. [DOI] [PMID: 11744710]
2.	Nishiya, Y. and Imanaka, T. Purification and characterization of a novel glycine oxidase from Bacillus subtilis. FEBS Lett. 438 (1998) 263–266. [DOI] [PMID: 9827558]

[EC 1.4.3.19 created 2002, modified 2012]