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Your query returned 1 entry. Printable version
EC | 1.4.3.5 | ||||||||||||||
Accepted name: | pyridoxal 5′-phosphate synthase | ||||||||||||||
Reaction: | (1) pyridoxamine 5′-phosphate + H2O + O2 = pyridoxal 5′-phosphate + NH3 + H2O2 (2) pyridoxine 5′-phosphate + O2 = pyridoxal 5′-phosphate + H2O2 |
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For diagram of pyridoxal biosynthesis, click here | |||||||||||||||
Glossary: | pyridoxamine = 4-aminomethyl-3-hydroxy-5-hydroxymethyl-2-methylpyridine | ||||||||||||||
Other name(s): | pyridoxamine 5′-phosphate oxidase; pyridoxamine phosphate oxidase; pyridoxine (pyridoxamine)phosphate oxidase; pyridoxine (pyridoxamine) 5′-phosphate oxidase; pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating); PMP oxidase; pyridoxol-5′-phosphate:oxygen oxidoreductase (deaminating) (incorrect); pyridoxamine-phosphate oxidase; PdxH | ||||||||||||||
Systematic name: | pyridoxamine-5′-phosphate:oxygen oxidoreductase (deaminating) | ||||||||||||||
Comments: | A flavoprotein (FMN). In Escherichia coli, the cofactor pyridoxal 5′-phosphate is synthesized de novo by a pathway that involves EC 1.2.1.72 (erythrose-4-phosphate dehydrogenase), EC 1.1.1.290 (4-phosphoerythronate dehydrogenase), EC 2.6.1.52 (phosphoserine transaminase), EC 1.1.1.262 (4-hydroxythreonine-4-phosphate dehydrogenase), EC 2.6.99.2 (pyridoxine 5′-phosphate synthase) and EC 1.4.3.5 (with pyridoxine 5′-phosphate as substrate). N4′-Substituted pyridoxamine derivatives are also oxidized in reaction (1) to form pyridoxal 5-phosphate and the corresponding primary amine. | ||||||||||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9029-21-4 | ||||||||||||||
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