ExplorEnz: EC 1.5.1.1

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1.5.1.1

Accepted name:

1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase [NAD(P)H]

Reaction:

(1) L-pipecolate + NAD(P)⁺ = 1-piperideine-2-carboxylate + NAD(P)H + H⁺
(2) L-proline + NAD(P)⁺ = 1-pyrroline-2-carboxylate + NAD(P)H + H⁺

Other name(s):

Δ¹-pyrroline-2-carboxylate reductase; DELTA1-pyrroline-2-carboxylate reductase; DELTA1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (ambiguous); AbLhpI; pyrroline-2-carboxylate reductase; L-proline:NAD(P)⁺ 2-oxidoreductase

Systematic name:

L-pipecolate/L-proline:NAD(P)⁺ 2-oxidoreductase

Comments:

The enzymes, characterized from the bacterium Azospirillum brasilense, is involved in trans-3-hydroxy-L-proline metabolism. In contrast to EC 1.5.1.21, 1-piperideine-2-carboxylate/1-pyrroline-2-carboxylate reductase (NADPH), which is specific for NADPH, this enzyme shows similar activity with NADPH and NADH.

Links to other databases:

BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9029-16-7

References:

1.	Meister, A., Radhakrishnan, A.N. and Buckley, S.D. Enzymatic synthesis of L-pipecolic acid and L-proline. J. Biol. Chem. 229 (1957) 789–800. [PMID: 13502341]
2.	Watanabe, S., Tanimoto, Y., Yamauchi, S., Tozawa, Y., Sawayama, S. and Watanabe, Y. Identification and characterization of trans-3-hydroxy-L-proline dehydratase and Δ¹-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-L-proline metabolism of bacteria. FEBS Open Bio 4 (2014) 240–250. [DOI] [PMID: 24649405]

[EC 1.5.1.1 created 1961, modified 2015]